FAPESP Young Investigator Project – Identification of Viruses with Zoonotic Potential in the Rodent Population of São Paulo: Monitoring, Diagnosis, and Characterization
Project leader: Robert Andreata Santos
The growing occurrence of viral zoonotic outbreaks with economic and epidemiological impact reinforces the importance of studies that expand our understanding of the agents involved in their emergence. Although rodents live in close contact with human populations in major urban centers, information on the diversity of viruses they carry and their role in maintaining and spreading these agents remains limited.
This project aims to identify and characterize viruses with zoonotic potential in rodent populations in the city of São Paulo by collecting and analyzing tissues and fecal samples obtained from infestation areas. The samples will undergo molecular screening protocols and next-generation sequencing (NGS), followed by bioinformatic analyses to detect relevant mutations and genetic signatures. Identified viruses will be isolated and characterized in vitro, and the resulting data will be integrated with environmental variables and human serological information to assess possible transmission correlations. The findings will contribute to strengthening viral zoonosis surveillance and improving the understanding of the interface between the urban environment and public health.
Educational and Training Grant (Global Virus Network – GVN) – Urban Virome Surveillance: Investigating Viral Diversity in Fecal Samples from Rattus norvegicus in São Paulo, Brazil
Project leader: Robert Andreata Santos
The central goal of this project is to identify and characterize circulating viruses found in fecal samples from urban rodent populations in the city of São Paulo, recognizing the importance of understanding the role of such samples in the potential transmission of viral zoonoses. The generated data will enable mapping viral diversity, geographic distribution, and correlations with environmental and socioeconomic factors. The project aims to produce essential information for public health surveillance and is aligned with the Global Virus Network’s mission to strengthen global preparedness for future epidemics.